Ac-(D-Trp¹⁶)-Endothelin-1 (16-21)

Description:

The hexapeptide binds specifically to the pituitary GnRH receptor exhibiting agonistic activity.

Sequence:

Ac-{D-Trp}LDIIW

General

References

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Name	Ac-(D-Trp¹⁶)-Endothelin-1 (16-21)
Category	Endothelins and Related Peptides
One Letter Code	Ac-{D-Trp}LDIIW
Three Letter Code	Acetylation-{D-Trp}{Leu}{Asp}{Ile}{Ile}{Trp}
Molecular Weight	887.050
Application	Cardiovascular System & Diseases

Yahalom, Dror, et al. "Hexapeptide and cyclic pentapeptide endothelin antagonists directly activate pituitary gonadotropin-releasing hormone receptors." Molecular pharmacology 57.4 (2000): 718-724.

Cody, Wayne L., et al. "Design of a functional hexapeptide antagonist of endothelin." Journal of medicinal chemistry 35.17 (1992): 3301-3303.