Elafin

Description:

Elafin is a potent inhibitor of HNE and proteinase 3 produced in the skin and the airways

Sequence:

AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ (Disulfide bridge: 16- 45, 23-49, 32- 44, 38- 53)

General

References

Comments (0)

Name	Elafin
Category	Disulfide Cyclized Peptides
One Letter Code	AQEPVKGPVSTKPGSCPIILIRCAMLNPPNRCLKDTDCPGIKKCCEGSCGMACFVPQ (Disulfide bridge: 16- 45, 23-49, 32- 44, 38- 53)
Three Letter Code	{Ala}{Gln}{Glu}{Pro}{Val}{Lys}{Gly}{Pro}{Val}{Ser}{Thr}{Lys}{Pro}{Gly}{Ser}{Cys}{Pro}{Ile}{Ile}{Leu}{Ile}{Arg}{Cys}{Ala}{Met}{Leu}{Asn}{Pro}{Pro}{Asn}{Arg}{Cys}{Leu}{Lys}{Asp}{Thr}{Asp}{Cys}{Pro}{Gly}{Ile}{Lys}{Lys}{Cys}{Cys}{Glu}{Gly}{Ser}{Cys}{Gly}{Met}{Ala}{Cys}{Phe}{Val}{Pro}{Gln} (Disulfide bridge: 16-45, 23-49, 32-44, 38-53) (Disulfide bridge: 16- 45, 23-49, 32- 44, 38- 53)
Molecular Weight	5999.300
Application

King, Anne E., et al. "Elafin in human endometrium: an antiprotease and antimicrobial molecule expressed during menstruation." The Journal of Clinical Endocrinology & Metabolism 88.9 (2003): 4426-4431.

Wiedow, Oliver, Jens Lüdemann, and Bert Utecht. "Elafin is a potent inhibitor of proteinase 3." Biochemical and biophysical research communications 174.1 (1991): 6-10.

Tremblay, Guy M., et al. "Elafin/elastase-specific inhibitor in bronchoalveolar lavage of normal subjects and farmer's lung." American journal of respiratory and critical care medicine 154.4 (1996): 1092-1098.

Simpson, A. John, et al. "Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection." The Journal of Immunology 167.3 (2001): 1778-1786.