(Lys⁷)-Dermorphin

Description:

(Lys⁷)-Dermorphin is a mu1 receptor agonist with stronger analgesic property than morphine.

Sequence:

Y{D-Ala}FGYPK-NH₂

General

References

Comments (0)

Name	(Lys⁷)-Dermorphin
Category	Deltorphins and Dermorphins
One Letter Code	Y{D-Ala}FGYPK-NH₂
Three Letter Code	{Tyr}{D-Ala}{Phe}{Gly}{Tyr}{Pro}{Lys}-NH₂
Molecular Weight	843.980
Application	Opioid Research

Pontieri, Francesco E., et al. "Effects of the intravenous administration of [Lys7] dermorphin on local cerebral glucose utilization in the rat." European journal of pharmacology 544.1-3 (2006): 17-20.

Negri, Lucia, Roberta Lattanzi, and Pietro Melchiorri. "Production of antinociception by peripheral administration of [Lys7] dermorphin, a naturally occurring peptide with high affinity for mu-opioid receptors." British journal of pharmacology 114.1 (1995): 57.

Negri, Lucia, et al. "Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two mu opioid receptor subtypes that modulate antinociception and catalepsy in the rat." Proceedings of the National Academy of Sciences 89.15 (1992): 7203-7207.