H-Trp-Lys-Tyr-Met-Val-Met-NH₂

Description:

WKYMVM-NH₂ activates exclusively the N-formylpeptide receptors FPRL1 and FPRL2 contrary to its epimer WKYMVm-NH₂ which activates all three receptors.

Sequence:

WKYMVM-NH₂

General

References

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Name	H-Trp-Lys-Tyr-Met-Val-Met-NH₂
Category	Chemotactic Factors and Related Peptides
One Letter Code	WKYMVM-NH₂
Three Letter Code	{Trp}{Lys}{Tyr}{Met}{Val}{Met}-NH₂
Molecular Weight	856.120
Application	Inflammation Research

Douthwaite, Julie A., et al. "Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1." MAbs. Vol. 7. No. 1. Taylor & Francis, 2015.

Christophe, Thierry, et al. "The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2." Journal of Biological Chemistry 276.24 (2001): 21585-21593.