H-Trp-Lys-Tyr-Met-Val-D-Met-NH₂

Description:

This fragment could stimulate monocytes, neutrophils, and dendritic cells (DCs). The peptide chemoattracts DCs, increases their phagocytic activity and inhibits their LPS-induced maturation via formyl peptide receptor (FPR) and formyl peptide receptor-like 2 (FPRL2).

Sequence:

WKYMV{D-Met}-NH₂

General

References

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Name	H-Trp-Lys-Tyr-Met-Val-D-Met-NH₂
Category	Chemotactic Factors and Related Peptides
One Letter Code	WKYMV{D-Met}-NH₂
Three Letter Code	{Trp}{Lys}{Tyr}{Met}{Val}{D-Met}-NH₂
Molecular Weight	856.120
Application	Inflammation Research

Young, Susan M., et al. "Duplex high‐throughput flow cytometry screen identifies two novel formylpeptide receptor family probes." Cytometry Part A: The Journal of the International Society for Advancement of Cytometry 75.3 (2009): 253-263.

Karlsson, Jennie, et al. "The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptde receptor like 1 is blocked: a receptor switch with implications for signal transduction studies with inhibitors and receptor antagonists." Biochemical pharmacology 71.10 (2006): 1488-1496.

Lee, Chang Geun, et al. "The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met as a novel adjuvant for DNA vaccine." Vaccine 23.38 (2005): 4703-4710.

Baek, Suk Hwan, et al. "Identification of the peptides that stimulate the phosphoinositide hydrolysis in lymphocyte cell lines from peptide libraries." Journal of Biological Chemistry 271.14 (1996): 8170-8175.