SDF-1β (human)

Description:

SDF-1 is involved in several pathological conditions such as AIDS, cancer cell metastasis, leukemia cell progression, rheumatoid arthritis and pulmonary fibrosis

Sequence:

KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM (Disulfide bridge: 9 - 34, 11 - 50)

General

References

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Name	SDF-1β (human)
Category	Chemokines and Cytokines
One Letter Code	KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM (Disulfide bridge: 9 - 34, 11 - 50)
Three Letter Code	{Lys}{Pro}{Val}{Ser}{Leu}{Ser}{Tyr}{Arg}{Cys}{Pro}{Cys}{Arg}{Phe}{Phe}{Glu}{Ser}{His}{Val}{Ala}{Arg}{Ala}{Asn}{Val}{Lys}{His}{Leu}{Lys}{Ile}{Leu}{Asn}{Thr}{Pro}{Asn}{Cys}{Ala}{Leu}{Gln}{Ile}{Val}{Ala}{Arg}{Leu}{Lys}{Asn}{Asn}{Asn}{Arg}{Gln}{Val}{Cys}{Ile}{Asp}{Pro}{Lys}{Leu}{Lys}{Trp}{Ile}{Gln}{Glu}{Tyr}{Leu}{Glu}{Lys}{Ala}{Leu}{Asn}{Lys}{Arg}{Phe}{Lys}{Met} (Disulfide bridge: 9-34, 11-50) (Disulfide bridge: 9 - 34, 11 - 50)
Molecular Weight	8522.170
Application	Cancer ResearchInfectious DiseaseRegenerative Medicine

Tamamura, Hirokazu, Hiroshi Tsutsumi, and Nobutaka Fujii. "The chemokine receptor CXCR4 as a therapeutic target for several diseases." Mini reviews in medicinal chemistry 6.9 (2006): 989-995.

De La Luz Sierra, Maria, et al. "Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity." Blood 103.7 (2004): 2452-2459.

Müller, Anja, et al. "Involvement of chemokine receptors in breast cancer metastasis." nature 410.6824 (2001): 50-56.