SDF-1α (human)

Description:

SDF-1α is involved in several pathological conditions such as rheumatoid arthritis, pulmonary fibrosis, metastasis and leukemia cell progression.

Sequence:

KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK (Disulfide bridge: 9 - 34, 11 - 50)

General

References

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Name	SDF-1α (human)
Category	Chemokines and Cytokines
One Letter Code	KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK (Disulfide bridge: 9 - 34, 11 - 50)
Three Letter Code	{Lys}{Pro}{Val}{Ser}{Leu}{Ser}{Tyr}{Arg}{Cys}{Pro}{Cys}{Arg}{Phe}{Phe}{Glu}{Ser}{His}{Val}{Ala}{Arg}{Ala}{Asn}{Val}{Lys}{His}{Leu}{Lys}{Ile}{Leu}{Asn}{Thr}{Pro}{Asn}{Cys}{Ala}{Leu}{Gln}{Ile}{Val}{Ala}{Arg}{Leu}{Lys}{Asn}{Asn}{Asn}{Arg}{Gln}{Val}{Cys}{Ile}{Asp}{Pro}{Lys}{Leu}{Lys}{Trp}{Ile}{Gln}{Glu}{Tyr}{Leu}{Glu}{Lys}{Ala}{Leu}{Asn}{Lys} (Disulfide bridge: 9-34, 11-50) (Disulfide bridge: 9 - 34, 11 - 50)
Molecular Weight	7959.430
Application	Cancer ResearchCell CultureCytokines/Chemokines & their ReceptorsInfectious DiseaseRegenerative Medicine

Iwamoto, Takuji, et al. "Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients." The FEBS journal 275.18 (2008): 4448-4455.

Xu, Jianguo, et al. "Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis." American journal of respiratory cell and molecular biology 37.3 (2007): 291-299.

Kalinkovich, Alexander, et al. "Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells." Cancer research 66.22 (2006): 11013-11020.

De La Luz Sierra, Maria, et al. "Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity." Blood 103.7 (2004): 2452-2459.

Müller, Anja, et al. "Involvement of chemokine receptors in breast cancer metastasis." nature 410.6824 (2001): 50-56.