TAT (47 - 57)/HIV-1 tat Protein (47-57)

Description:

A cell-permeable peptide (CPP) derived from the HIV-1 tat protein transduction domain (PTD). This fragment promotes the entry of nucleic acids into several cell types.

Sequence:

YGRKKRRQRRR
  • General
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  • Name TAT (47 - 57)/HIV-1 tat Protein (47-57)
    Category Cell Permeable Peptides (CPP) / Drug Delivery Peptides
    One Letter Code YGRKKRRQRRR
    Three Letter Code {Tyr}{Gly}{Arg}{Lys}{Lys}{Arg}{Arg}{Gln}{Arg}{Arg}{Arg}
    Molecular Weight 1559.900
    Application Cell-permeable Peptides, Infectious Disease,HIV Related Peptides
    Ziegler, André, et al. "The cationic cell-penetrating peptide CPPTAT derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence." Biochemistry 44.1 (2005): 138-148.
    Freire, João M., et al. "Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action." The FEBS journal 281.1 (2014): 191-215.
    Freire, João Miguel, et al. "Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein." PloS one 8.12 (2013).
    Mao, Zhengwei, et al. "Tat peptide mediated cellular uptake of SiO2 submicron particles." Colloids and Surfaces B: Biointerfaces 75.2 (2010): 432-440.
    Ziegler, André, et al. "The cationic cell-penetrating peptide CPPTAT derived from the HIV-1 protein TAT is rapidly transported into living fibroblasts: optical, biophysical, and metabolic evidence." Biochemistry 44.1 (2005): 138-148.
    Sarkar, Tumpa, et al. "Condensation of oligonucleotides assembled into nicked and gapped duplexes: potential structures for oligonucleotide delivery." Nucleic acids research 33.1 (2005): 143-151.
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