Penetratin amide

Description:

Penetratin linked to a phosphodiester oligonucleotide is capable of permeating through neuronal cell membranes and down-regulating genes. Penetratin is also known as a protein transduction domain (PTD). It has antimicrobial and antifungal activity

Sequence:

RQIKIWFQNRRMKWKK-NH₂

General

References

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Name	Penetratin amide
Category	Cell Permeable Peptides (CPP) / Drug Delivery Peptides
One Letter Code	RQIKIWFQNRRMKWKK-NH₂
Three Letter Code	{Arg}{Gln}{Ile}{Lys}{Ile}{Trp}{Phe}{Gln}{Asn}{Arg}{Arg}{Met}{Lys}{Trp}{Lys}{Lys}-NH₂
Molecular Weight	2245.780
Application	Cell-permeable Peptides

Garibotto, Francisco M., et al. "Penetratin analogues acting as antifungal agents." European journal of medicinal chemistry 46.1 (2011): 370-377.

Zhu, Wan Long, and Song Yub Shin. "Antimicrobial and cytolytic activities and plausible mode of bactericidal action of the cell penetrating peptide penetratin and its Lys‐linked two‐stranded peptide." Chemical biology & drug design 73.2 (2009): 209-215.

Dom, Geneviève, et al. "Cellular uptake of Antennapedia Penetratin peptides is a two‐step process in which phase transfer precedes a tryptophan‐dependent translocation." Nucleic acids research 31.2 (2003): 556-561.