Mastoparan

Description:

This 14-residue peptide toxin induces mitochondrial membrane permeabilization via a CsA-inhibitable mechanism.

Sequence:

INLKALAALAKKIL-NH2

General

References

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Name	Mastoparan
Category	Cell Permeable Peptides (CPP) / Drug Delivery Peptides
One Letter Code	INLKALAALAKKIL-NH2
Three Letter Code	{Ile}{Asn}{Leu}{Lys}{Ala}{Leu}{Ala}{Ala}{Leu}{Ala}{Lys}{Lys}{Ile}{Leu}-NH2
Molecular Weight	1478.900
Application	Cell-permeable PeptidesInflammation Research

Hori, Yumiko, et al. "Interaction of mastoparan with membranes studied by 1H‐NMR spectroscopy in detergent micelles and by solid‐state 2H‐NMR and 15N‐NMR spectroscopy in oriented lipid bilayers." European journal of biochemistry 268.2 (2001): 302-309.

Hirata, Yutaka, Norimichi Nakahata, and Yasushi Ohizumi. "Identification of a 97-kDa mastoparan-binding protein involving in Ca2+ release from skeletal muscle sarcoplasmic reticulum." Molecular pharmacology 57.6 (2000): 1235-1242.

Yajima, Yukiko, et al. "Mastoparan-stimulated prolactin secretion in rat pituitary GH3 cells involves activation of Gq/11 proteins." Endocrinology 138.5 (1997): 1949-1958.

Sukumar, Muppalla, Elliott M. Ross, and Tsutomu Higashijima. "A Gs-selective analog of the receptor-mimetic peptide mastoparan binds to Gsα in a kinked helical conformation." Biochemistry 36.12 (1997): 3632-3639.