NGR Peptide 1

Description:

This peptide shows potent cytotoxicity and activity against tumor cells due to its binding to CD13 on tumor cells.

Sequence:

CNGRCGG{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}-NH2 (Disulfide bridge: 1 - 5)

General

References

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Name	NGR Peptide 1
Category	Cell Permeable Peptides (CPP) / Drug Delivery Peptides
One Letter Code	CNGRCGG{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}-NH2 (Disulfide bridge: 1 - 5)
Three Letter Code	{Cys}{Asn}{Gly}{Arg}{Cys}{Gly}{Gly}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Lys}{D-Leu}{D-Ala}{D-Lys}{D-Leu}{D-Ala}{D-Lys}-NH2 (Disulfide bridge: 1-5) (Disulfide bridge: 1 - 5)
Molecular Weight	2168.700
Application	Cell-permeable Peptides

Ellerby, H. Michael, et al. "Anti-cancer activity of targeted pro-apoptotic peptides." Nature medicine 5.9 (1999): 1032-1038.

Colombo, Giorgio, et al. "Structure-activity relationships of linear and cyclic peptides containing the NGR tumor-homing motif." Journal of Biological Chemistry 277.49 (2002): 47891-47897.

Van Hensbergen, Yvette, et al. "A doxorubicin–CNGRC-peptide conjugate with prodrug properties." Biochemical pharmacology 63.5 (2002): 897-908.

Plesniak, Leigh A., et al. "Orientation and helical conformation of a tissue‐specific hunter‐killer peptide in micelles." Protein science 13.8 (2004): 1988-1996.