Pep - 1 - Cysteamine

Description:

Pep-1 is one of the synthetic cell-penetrating peptides (CPPs), which has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive way. The presence of cysteamine group in C terminal seems to play a crucial role in the delivery efficiency of cargoes into cells.

Sequence:

Ac-KETWWETWWTEWSQPKKKRKV-cysteamine

General

References

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Name	Pep - 1 - Cysteamine
Category	Cell Permeable Peptides (CPP) / Drug Delivery Peptides
One Letter Code	Ac-KETWWETWWTEWSQPKKKRKV-cysteamine
Three Letter Code	Ac-{Lys}{Glu}{Thr}{Trp}{Trp}{Glu}{Thr}{Trp}{Trp}{Thr}{Glu}{Trp}{Ser}{Gln}{Pro}{Lys}{Lys}{Lys}{Arg}{Lys}{Val}-cysteamine
Molecular Weight	2949.500
Application	Cell-permeable Peptides

Henriques, Sónia T., Júlia Costa, and Miguel ARB Castanho. "Re‐evaluating the role of strongly charged sequences in amphipathic cell‐penetrating peptides: A fluorescence study using Pep‐1." FEBS letters 579.20 (2005): 4498-4502.

Morris, May C., et al. "A peptide carrier for the delivery of biologically active proteins into mammalian cells." Nature biotechnology 19.12 (2001): 1173-1176.