Caspase 1 (ICE) Substrate 3f, fluorogenic

Description:

AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities.

Sequence:

Ac-WEHD-AFC

General

References

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Name	Caspase 1 (ICE) Substrate 3f, fluorogenic
Category	Caspase Related Peptides
One Letter Code	Ac-WEHD-AFC
Three Letter Code	Acetylation-{Trp}{Glu}{His}{Asp}-AFC
Molecular Weight	838.600
Application	Apoptosis & Necrosis

Gurtu, Vanessa, Steven R. Kain, and Guohong Zhang. "Fluorometric and colorimetric detection of caspase activity associated with apoptosis." Analytical biochemistry 251.1 (1997): 98-102.

Martins, Luis M., et al. "Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis." Journal of Biological Chemistry 272.11 (1997): 7421-7430.

Deveraux, Quinn L., et al. "X-linked IAP is a direct inhibitor of cell-death proteases." Nature 388.6639 (1997): 300-304.

Datta, Debajyoti, et al. "An allosteric circuit in caspase-1." Journal of molecular biology 381.5 (2008): 1157-1167.