Caspase 9 Substrate 1f, fluorogenic

Description:

AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities.

Sequence:

Ac-LEHD-AFC

General

References

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Name	Caspase 9 Substrate 1f, fluorogenic
Category	Caspase Related Peptides
One Letter Code	Ac-LEHD-AFC
Three Letter Code	Acetylation-{Leu}{Glu}{His}{Asp}-AFC
Molecular Weight	765.600
Application	Apoptosis & Necrosis

Leyva, Melissa J., et al. "Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models." Chemistry & biology 17.11 (2010): 1189-1200.

Vrba, Jiří, et al. "Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells." Toxicology in vitro 23.4 (2009): 580-588.

Leifeld, L., et al. "Keratin 18 provides resistance to Fas‐mediated liver failure in mice." European journal of clinical investigation 39.6 (2009): 481-488.

Vrba, Jiří, et al. "Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells." Toxicology in vitro 22.4 (2008): 1008-1017.

Leifeld, Ludger, et al. "Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo." The American journal of pathology 168.3 (2006): 778-785.

Hill, Michelle M., et al. "Analysis of the composition, assembly kinetics and activity of native Apaf‐1 apoptosomes." The EMBO journal 23.10 (2004): 2134-2145.