Caspase 8 Substrate 1f, fluorogenic

Description:

AFC (7-amino-4-trifluoromethylcoumarin)-derived caspase substrates are widely used for the fluorimetric detection of various caspase activities.

Sequence:

Ac-IETD-AFC

General

References

Comments (0)

Name	Caspase 8 Substrate 1f, fluorogenic
Category	Caspase Related Peptides
One Letter Code	Ac-IETD-AFC
Three Letter Code	Acetylation-{Ile}{Glu}{Thr}{Asp}-AFC
Molecular Weight	729.600
Application	Apoptosis Peptides

Gurtu, Vanessa, Steven R. Kain, and Guohong Zhang. "Fluorometric and colorimetric detection of caspase activity associated with apoptosis." Analytical biochemistry 251.1 (1997): 98-102.

Martins, Luis M., et al. "Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis." Journal of Biological Chemistry 272.11 (1997): 7421-7430.

Deveraux, Quinn L., et al. "X-linked IAP is a direct inhibitor of cell-death proteases." Nature 388.6639 (1997): 300-304.

Xiang, Jialing, Debra T. Chao, and Stanley J. Korsmeyer. "BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases." Proceedings of the National Academy of Sciences 93.25 (1996): 14559-14563.