Z-Ile-Glu-Thr-Asp-AFC

Description:

Substrate for granzyme B.

Sequence:

Z-IETD-AFC

General

References

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Name	Z-Ile-Glu-Thr-Asp-AFC
Category	Caspase Inhibitors and Substrates
One Letter Code	Z-IETD-AFC
Three Letter Code	Z-{Ile}{Glu}{Thr}{Asp}-AFC
Molecular Weight	821.760
Application	Apoptosis & Necrosis

Schickling, O., et al. "Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription." Cell Death & Differentiation 8.12 (2001): 1157-1168.

Han, Zhiyong, et al. "A sequential two-step mechanism for the production of the mature p17: p12 form of caspase-3 in vitro." Journal of Biological Chemistry 272.20 (1997): 13432-13436.