Ac-Ile-Glu-Thr-Asp-AMC

Description:

fluorogenic substrate for caspase-8 and granzyme B.

Sequence:

Ac-IETD-AMC

General

References

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Name	Ac-Ile-Glu-Thr-Asp-AMC
Category	Caspase Inhibitors and Substrates
One Letter Code	Ac-IETD-AMC
Three Letter Code	Acetylation-{Ile}{Glu}{Thr}{Asp}-AMC
Molecular Weight	675.690
Application	Apoptosis & Necrosis

Finot, Francis, et al. "Combined Stimulation with the Tumor Necrosis Factor and the Epidermal Growth Factor Promotes the Proliferation of Hepatocytes in Rat Liver Cultured Slices." International journal of hepatology 2012 (2012).

Sonnemann, Juergen, et al. "Histone deacetylase inhibitor-mediated sensitization to TRAIL-induced apoptosis in childhood malignancies is not associated with upregulation of TRAIL receptor expression, but with potentiated caspase-8 activation." Cancer biology & therapy 13.6 (2012): 417-424.

Lafont, Elodie, et al. "Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk." PloS one 5.10 (2010).

Badiola, Nahuai, et al. "Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen–glucose deprived cultured cortical cells." Neurobiology of Disease 35.3 (2009): 438-447.

He, Rui, et al. "Metacaspase-8 modulates programmed cell death induced by ultraviolet light and H2O2 in Arabidopsis." Journal of Biological Chemistry 283.2 (2008): 774-783.