Ac-Ile-Glu-Pro-Asp-pNA

Description:

The caspase substrate Ac-IEPD-pNA containing the granzyme B cleavage site was proposed as a potential granzyme B target. It was shown to be the optimal P4-P1 substrate sequence for granzyme B.

Sequence:

Ac-IEPD-pNA

General

References

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Name	Ac-Ile-Glu-Pro-Asp-pNA
Category	Caspase Inhibitors and Substrates
One Letter Code	Ac-IEPD-pNA
Three Letter Code	Acetylation-{Ile}{Glu}{Pro}{Asp}-p-Nitroanilide
Molecular Weight	634.640
Application	Apoptosis & Necrosis

Harris, Jennifer L., et al. "Definition and redesign of the extended substrate specificity of granzyme B." Journal of Biological Chemistry 273.42 (1998): 27364-27373.