Ac-Ile-Glu-Pro-Asp-AMC

Description:

Ac-IEPD-AMC is a preferred substrate sequence of granzyme B, a mammalian serine protease involved in the induction of rapid target cell death by cytotoxic lymphocytes.

Sequence:

Ac-IEPD-AMC

General

References

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Name	Ac-Ile-Glu-Pro-Asp-AMC
Category	Caspase Inhibitors and Substrates
One Letter Code	Ac-IEPD-AMC
Three Letter Code	Acetylation-{Ile}{Glu}{Pro}{Asp}-AMC
Molecular Weight	671.710
Application	Apoptosis & Necrosis

Barczyk, Katarzyna, et al. "Glucocorticoids promote survival of anti-inflammatory macrophages via stimulation of adenosine receptor A3." Blood, The Journal of the American Society of Hematology 116.3 (2010): 446-455.

Mahrus, Sami, Walter Kisiel, and Charles S. Craik. "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B." Journal of Biological Chemistry 279.52 (2004): 54275-54282.

Harris, Jennifer L., et al. "Definition and redesign of the extended substrate specificity of granzyme B." Journal of Biological Chemistry 273.42 (1998): 27364-27373.