RYR2 (2460 - 2495)

Description:

This is amino acids 2460 to 2495 fragment of cardiac ryanodine receptor (RyR2). RyR2 controls calcium release from the sarcoplasmic reticulum, which begins muscle contraction. Mutated RyR2 is associated to ventricular tachycardia (VT) and sudden death.

Sequence:

GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP

General

References

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Name	RYR2 (2460 - 2495)
Category	Cardiovascular Related Peptides
One Letter Code	GFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLP
Three Letter Code	{Gly}{Phe}{Cys}{Pro}{Asp}{His}{Lys}{Ala}{Ala}{Met}{Val}{Leu}{Phe}{Leu}{Asp}{Arg}{Val}{Tyr}{Gly}{Ile}{Glu}{Val}{Gln}{Asp}{Phe}{Leu}{Leu}{His}{Leu}{Leu}{Glu}{Val}{Gly}{Phe}{Leu}{Pro}
Molecular Weight	4103.900
Application	Cardiovascular System & Diseases

Jiang, Dawei, et al. "RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)." Proceedings of the National Academy of Sciences 101.35 (2004): 13062-13067.