Endotrophin (mouse)

Description:

Endotrophin is a carboxyl-terminal cleavage product of collagen 6 alpha-3 chain which is produced and released by adipocytes and massively upregulated in malignant tumors of breast, liver colon and pancreas. Endotrophin may serve as sensitive diagnostic marker and valid therapeutic target for treating cancer and ameliorating obesity-induced insulin resistance.

Sequence:

TEPLFLTKTDICKLSRDAGTCVDFKLLWHYDLESKSCKRFWYGGCGGNENRFHSQEECEKMCSPELTV

General

References

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Name	Endotrophin (mouse)
Category	Cancer Research Peptides
One Letter Code	TEPLFLTKTDICKLSRDAGTCVDFKLLWHYDLESKSCKRFWYGGCGGNENRFHSQEECEKMCSPELTV
Three Letter Code	{Thr}{Glu}{Pro}{Leu}{Phe}{Leu}{Thr}{Lys}{Thr}{Asp}{Ile}{Cys}{Lys}{Leu}{Ser}{Arg}{Asp}{Ala}{Gly}{Thr}{Cys}{Val}{Asp}{Phe}{Lys}{Leu}{Leu}{Trp}{His}{Tyr}{Asp}{Leu}{Glu}{Ser}{Lys}{Ser}{Cys}{Lys}{Arg}{Phe}{Trp}{Tyr}{Gly}{Gly}{Cys}{Gly}{Gly}{Asn}{Glu}{Asn}{Arg}{Phe}{His}{Ser}{Gln}{Glu}{Glu}{Cys}{Glu}{Lys}{Met}{Cys}{Ser}{Pro}{Glu}{Leu}{Thr}{Val} (Disulfide bonds, air oxidized)
Molecular Weight	7876.940
Application	Cancer ResearchDiabetes

Park, J., T. S. Morley, and P. E. Scherer. "Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours, EMBO Mol." (2013).

Park, Jiyoung, and Philipp E. Scherer. "Adipocyte-derived endotrophin promotes malignant tumor progression." The Journal of clinical investigation 122.11 (2012): 4243-4256.

Park, Jiyoung, and Philipp E. Scherer. "Endotrophin–linking obesity with aggressive tumor growth." Oncotarget 3.12 (2012): 1487.