MUC1, tandem repeat fragment

Description:

This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein and is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma

Sequence:

PDTRPAPGSTAPPAHGVTSA

General

References

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Name	MUC1, tandem repeat fragment
Category	Cancer Research Peptides
One Letter Code	PDTRPAPGSTAPPAHGVTSA
Three Letter Code	{Pro}{Asp}{Thr}{Arg}{Pro}{Ala}{Pro}{Gly}{Ser}{Thr}{Ala}{Pro}{Pro}{Ala}{His}{Gly}{Val}{Thr}{Ser}{Ala}
Molecular Weight	1887.000
Application	Cancer Research

Brossart, Peter, et al. "Identification of HLA-A2–restricted T-cell epitopes derived from the MUC1 tumor antigen for broadly applicable vaccine therapies." Blood, The Journal of the American Society of Hematology 93.12 (1999): 4309-4317.

Wajchman, Howard J., et al. "Ex vivo expansion of CD8+ CD56+ and CD8+ CD56− natural killer T cells specific for MUC1 mucin." Cancer research 64.3 (2004): 1171-1180.