Melanocyte Protein PMEL 17 (130-138) (human)

Description:

PMEL 17 could be a melanogenic enzyme. This sequence is a gp100 epitope that is recognized in the context of HLA-A2 by tumor-infiltrating lymphocytes (TIL) in vivo.

Sequence:

KTWGQYWQV

General

References

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Name	Melanocyte Protein PMEL 17 (130-138) (human)
Category	Cancer Research Peptides
One Letter Code	KTWGQYWQV
Three Letter Code	{Lys}{Thr}{Trp}{Gly}{Gln}{Tyr}{Trp}{Gln}{Val}
Molecular Weight	1195.340
Application	Antigen-presenting CellsCancer Research

Nestle, Frank O., et al. "Vaccination of melanoma patients with peptide-or tumorlysate-pulsed dendritic cells." Nature medicine 4.3 (1998): 328-332.

Velders, Markwin P., et al. "Identification of peptides for immunotherapy of cancer. It is still worth the effort." Critical Reviews™ in Immunology 18.1-2 (1998).

Salgaller, Michael L., et al. "Immunization against epitopes in the human melanoma antigen gp100 following patient immunization with synthetic peptides." Cancer research 56.20 (1996): 4749-4757.

Parkhurst, Maria R., et al. "Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A* 0201-binding residues." The Journal of Immunology 157.6 (1996): 2539-2548.

Salgaller, Michael L., et al. "Recognition of multiple epitopes in the human melanoma antigen gp100 by peripheral blood lymphocytes stimulated in vitro with synthetic peptides." Cancer research 55.21 (1995): 4972-4979.