Bid BH3 Peptide

Description:

Bid is a pro-apoptotic member of the 'BH3-only' subset of the BCL-2 family proteins that constitute a critical control point in apoptosis.

Sequence:

EDIIRNIARHLAQVGDSMDR

General

References

Comments (0)

Name	Bid BH3 Peptide
Category	Cancer Research Peptides
One Letter Code	EDIIRNIARHLAQVGDSMDR
Three Letter Code	{Glu}{Asp}{Ile}{Ile}{Arg}{Asn}{Ile}{Ala}{Arg}{His}{Leu}{Ala}{Gln}{Val}{Gly}{Asp}{Ser}{Met}{Asp}{Arg}
Molecular Weight	2309.600
Application

Oh, Kyoung Joon, et al. "Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding a SITE-DIRECTED SPIN LABELING STUDY." Journal of Biological Chemistry 280.1 (2005): 753-767.

Oh, Kyoung Joon, et al. "A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro." Journal of Biological Chemistry 281.48 (2006): 36999-37008.

Manero, Florence, et al. "The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death." Cancer research 66.5 (2006): 2757-2764.

Zhai, Dayong, et al. "Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak." Journal of Biological Chemistry 280.16 (2005): 15815-15824.

Walensky, Loren D., et al. "A stapled BID BH3 helix directly binds and activates BAX." Molecular cell 24.2 (2006): 199-210.

Onuki, Reiko, et al. "Confirmation by FRET in individual living cells of the absence of significant amyloid β-mediated caspase 8 activation." Proceedings of the National Academy of Sciences 99.23 (2002): 14716-14721.