Collagen Type IV α3 Chain (185-203)

Description:

The collagen IV fragment inhibits the activation of polymorphonuclear leukocytes. It promotes adhesion of human melanoma cells and inhibits their proliferation.

Sequence:

CNYYSNSYSFWLASLNPER

General

References

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Name	Collagen Type IV α3 Chain (185-203)
Category	Cancer Research Peptides
One Letter Code	CNYYSNSYSFWLASLNPER
Three Letter Code	{Cys}{Asn}{Tyr}{Tyr}{Ser}{Asn}{Ser}{Tyr}{Ser}{Phe}{Trp}{Leu}{Ala}{Ser}{Leu}{Asn}{Pro}{Glu}{Arg}
Molecular Weight	2314.520
Application	Cancer ResearchRegenerative Medicine

Pedchenko, Vadim, Roy Zent, and Billy G. Hudson. "αvβ3 and αvβ5 Integrins Bind Both the Proximal RGD Site and Non-RGD Motifs within Noncollagenous (NC1) Domain of the α3 Chain of Type IV Collagen Implication for The Mechanism of Endothelial Cell Adhesion." Journal of Biological Chemistry 279.4 (2004): 2772-2780.

Han, Jing, et al. "A cell binding domain from the α3 chain of type IV collagen inhibits proliferation of melanoma cells." Journal of Biological Chemistry 272.33 (1997): 20395-20401.

Monboisse, Jean-Claude, et al. "The alpha 3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes." Journal of Biological Chemistry 269.41 (1994): 25475-25482.