Smac-N7 Peptide

Description:

Smac-N7 Peptide, also known as DIABLO, is the N-terminal seven residues of Smac. Smac/DIABLO is a mitochondrial proapoptotic protein that could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs

Sequence:

AVPIAQK

General

References

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Name	Smac-N7 Peptide
Category	Cancer Research Peptides
One Letter Code	AVPIAQK
Three Letter Code	{Ala}{Val}{Pro}{Ile}{Ala}{Gln}{Lys}
Molecular Weight	725.890
Application	Apoptosis & NecrosisCancer Research

Fandy, Tamer E., Sharmila Shankar, and Rakesh K. Srivastava. "Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells." Molecular cancer 7.1 (2008): 60.

Srinivasula, Srinivasa M., et al. "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis." Nature 410.6824 (2001): 112-116.

Du, Chunying, et al. "Smac, a mitochondrial protein that promotes cytochrome c–dependent caspase activation by eliminating IAP inhibition." Cell 102.1 (2000): 33-42.

Chai, Jijie, et al. "Structural and biochemical basis of apoptotic activation by Smac/DIABLO." Nature 406.6798 (2000): 855-862.

Srinivasula, Srinivasa M., et al. "Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway." Journal of Biological Chemistry 275.46 (2000): 36152-36157.