VEGFR2/KDR Antagonist

Description:

This peptide is a specific VEGFR2/KDR heptapeptide antagonist. It completely inhibit VEGF binding to KDR and prevent VEGF-induced angiogenesis in-vivo by binding VEGFR2 (KDR/flk).

Sequence:

ATWLPPR

General

References

Comments (0)

Name	VEGFR2/KDR Antagonist
Category	Cancer Research Peptides
One Letter Code	ATWLPPR
Three Letter Code	{Ala}{Thr}{Trp}{Leu}{Pro}{Pro}{Arg}
Molecular Weight	840.000
Application

Renno, R., et al. "Selective targeting of verteporfin to choroidal neovascularization mediated by a homing peptide to VEGF-R2." Investigative Ophthalmology & Visual Science43.13 (2002): 3977-3977.

Brekken, Rolf A., et al. "Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice." Cancer research 60.18 (2000): 5117-5124.

Jia, Haiyan, et al. "Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells." Journal of Biological Chemistry 279.34 (2004): 36148-36157.

Binétruy‐Tournaire, Roselyne, et al. "Identification of a peptide blocking vascular endothelial growth factor (VEGF)‐mediated angiogenesis." The EMBO journal 19.7 (2000): 1525-1533.