Tyrosinase (206-214) (human)

Description:

The sequence AFLPWHRLF is a tyrosinase epitope recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL). It may be used to generate melanoma-specific T cells for adoptive immunotherapy, as well as in peptide vaccines for HLA-A24+ melanoma patients.

Sequence:

AFLPWHRLF

General

References

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Name	Tyrosinase (206-214) (human)
Category	Cancer Research Peptides
One Letter Code	AFLPWHRLF
Three Letter Code	{Ala}{Phe}{Leu}{Pro}{Trp}{His}{Arg}{Leu}{Phe}
Molecular Weight	1186.430
Application	Antigen-presenting CellsCancer Research

Bettinotti, Maria P., et al. "Frequency of human leukocyte antigen-A 24 alleles in patients with melanoma determined by human leukocyte antigen-A sequence-based typing." Journal of Immunotherapy 23.2 (2000): 282-287.

Kang, Xiaoqiang, et al. "Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes." The Journal of Immunology 155.3 (1995): 1343-1348.