MART-1 (27-35) (human)

Description:

Melan A is amino acid 27 to 35 fragment of the nonmutated melanoma-associated antigen MART-1/Melan A.The sequence AAGIGILTV is the immunodominant epitope recognized by most melanoma-specific, HLA-A*0201-restricted, cytotoxic T lymphocytes (CTL).

Sequence:

AAGIGILTV

General

References

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Name	MART-1 (27-35) (human)
Category	Cancer Research Peptides
One Letter Code	AAGIGILTV
Three Letter Code	{Ala}{Ala}{Gly}{Ile}{Gly}{Ile}{Leu}{Thr}{Val}
Molecular Weight	813.990
Application	Antigen-presenting Cells, Cancer Research

Nestle, Frank O., et al. "Vaccination of melanoma patients with peptide-or tumorlysate-pulsed dendritic cells." Nature medicine 4.3 (1998): 328-332.

Velders, Markwin P., et al. "Identification of peptides for immunotherapy of cancer. It is still worth the effort." Critical Reviews™ in Immunology 18.1-2 (1998).

Cormier, Janice N., et al. "Enhancement of cellular immunity in melanoma patients immunized with a peptide from MART-1/Melan A." The cancer journal from Scientific American 3.1 (1997): 37.

van Elsas, Andrea, et al. "Peptide‐pulsed dendritic cells induce tumoricidal cytotoxic T lymphocytes from healthy donors against stably HLA‐A* 0201‐binding peptides from the Melan‐A/MART‐1 self antigen." European journal of immunology 26.8 (1996): 1683-1689.