WP9QY, TNF - alpha Antagonist

Description:

This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor.

Sequence:

YCWSQYLCY (Disulfide bridge: 2 - 8)

General

References

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Name	WP9QY, TNF - alpha Antagonist
Category	Cancer Research Peptides
One Letter Code	YCWSQYLCY (Disulfide bridge: 2 - 8)
Three Letter Code	{Tyr}{Cys}{Trp}{Ser}{Gln}{Tyr}{Leu}{Cys}{Tyr} (Disulfide bridge: 2-8) (Disulfide bridge: 2 - 8)
Molecular Weight	1226.400
Application	Apoptosis & Necrosis

Vrielink, Johanna, et al. "Synthetic constrained peptide selectively binds and antagonizes death receptor 5." The FEBS journal 277.7 (2010): 1653-1665.

Saito, Hiroaki, et al. "A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti–tumor necrosis factor monoclonal antibody in murine collagen‐induced arthritis." Arthritis & Rheumatism 56.4 (2007): 1164-1174.

Kojima, Takefumi, et al. "Subcutaneous injections of a TNF-α antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis." Journal of medical and dental sciences 52.1 (2005): 91-99.