Amylin (1 - 37) (human) amide

Description:

Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. Amylin blocks the activation of glycogen synthase by insulin.

Sequence:

KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (Disulfide bridge: 2-7)

General

References

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Name	Amylin (1 - 37) (human) amide
Category	Amylin (IAPP) and Fragments
One Letter Code	KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 (Disulfide bridge: 2-7)
Three Letter Code	{Lys}{Cys}{Asn}{Thr}{Ala}{Thr}{Cys}{Ala}{Thr}{Gln}{Arg}{Leu}{Ala}{Asn}{Phe}{Leu}{Val}{His}{Ser}{Ser}{Asn}{Asn}{Phe}{Gly}{Ala}{Ile}{Leu}{Ser}{Ser}{Thr}{Asn}{Val}{Gly}{Ser}{Asn}{Thr}{Tyr}-NH2 (Disulfide bridge: 2-7) (Disulfide bridge: 2-7)
Molecular Weight	3903.300
Application	Diabetes

Schultz, Nina, et al. "Amylin alters human brain pericyte viability and NG2 expression." Journal of Cerebral Blood Flow & Metabolism 37.4 (2017): 1470-1482.

Okada, Alan K., et al. "Diabetic risk factors promote islet amyloid polypeptide misfolding by a common, membrane-mediated mechanism." Scientific reports 6.1 (2016): 1-10.

Vasconcelos, Bruno, et al. "Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo." Acta neuropathologica 131.4 (2016): 549-569.

Sciacca, Michele FM, et al. "The role of cholesterol in driving IAPP-membrane interactions." Biophysical journal 111.1 (2016): 140-151.

Sisnande, Tháyna, et al. "Monoconjugation of human amylin with methylpolyethyleneglycol." PloS one 10.10 (2015).

Bram, Yaron, et al. "Monitoring and targeting the initial dimerization stage of amyloid self‐assembly." Angewandte Chemie International Edition 54.7 (2015): 2062-2067.