α-CGRP (8-37) (human)

Description:

CGRP and calcitonin cross-react with each other at the levels of their distinct receptors. α-CGRP (8-37) is a selective antagonist for CGRP receptors. This fragment is a valuable tool to study the receptor characterization.

Sequence:

VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH₂

General

References

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Name	α-CGRP (8-37) (human)
Category	Calcitonin Gene-Related Peptide (CGRP) and Fragments
One Letter Code	VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH₂
Three Letter Code	{Val}{Thr}{His}{Arg}{Leu}{Ala}{Gly}{Leu}{Leu}{Ser}{Arg}{Ser}{Gly}{Gly}{Val}{Val}{Lys}{Asn}{Asn}{Phe}{Val}{Pro}{Thr}{Asn}{Val}{Gly}{Ser}{Lys}{Ala}{Phe}-NH₂
Molecular Weight	3125.630
Application

Bodkin, Jennifer V., et al. "Investigating the potential role of TRPA 1 in locomotion and cardiovascular control during hypertension." Pharmacology research & perspectives 2.4 (2014): e00052.

Nikitenko, Leonid L., et al. "Adrenomedullin haploinsufficiency predisposes to secondary lymphedema." Journal of Investigative Dermatology 133.7 (2013): 1768-1776.

Aslam, M., et al. "Intermedin (adrenomedullin2) stabilizes the endothelial barrier and antagonizes thrombin‐induced barrier failure in endothelial cell monolayers." British journal of pharmacology 165.1 (2012): 208-222.

Liu, LianSheng, Mohan Shenoy, and Pankaj Jay Pasricha. "Substance P and calcitonin gene related peptide mediate pain in chronic pancreatitis and their expression is driven by nerve growth factor." JOP: Journal of the pancreas 12.4 (2011): 389.

De Felice, Milena, et al. "Triptan‐induced latent sensitization: A possible basis for medication overuse headache." Annals of neurology 67.3 (2010): 325-337.

Meens, Merlijn JPMT, et al. "Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ETA-receptor complexes." PLoS One 5.6 (2010).