Ac-(Asn³⁰,Tyr³²)-Calcitonin (8-32) (salmon I)

Description:

AC187 is a potent and selective antagonist of amylin-induced hyperglycaemia and hyperlactaemia.

Sequence:

Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH₂

General

References

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Name	Ac-(Asn³⁰,Tyr³²)-Calcitonin (8-32) (salmon I)
Category	Calcitonin Gene-Related Peptide (CGRP) and Fragments
One Letter Code	Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH₂
Three Letter Code	Acetylation-{Val}{Leu}{Gly}{Lys}{Leu}{Ser}{Gln}{Glu}{Leu}{His}{Lys}{Leu}{Gln}{Thr}{Tyr}{Pro}{Arg}{Thr}{Asn}{Thr}{Gly}{Ser}{Asn}{Thr}{Tyr}-NH₂
Molecular Weight	2890.250
Application	Diabetes

Mietlicki-Baase, Elizabeth G., and Matthew R. Hayes. "Amylin activates distributed CNS nuclei to control energy balance." Physiology & behavior 136 (2014): 39-46.

Qi, Tao, et al. "Receptor activity‐modifying protein‐dependent impairment of calcitonin receptor splice variant Δ (1–47) hCT (a) function." British journal of pharmacology 168.3 (2013): 644-657.

Bailey, R. J., et al. "Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes." British journal of pharmacology 166.1 (2012): 151-167.

Hay, Debbie L., et al. "Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes." Molecular pharmacology 67.5 (2005): 1655-1665.

Piao, Feng Lian, et al. "Amylin-induced suppression of ANP secretion through receptors for CGRP1 and salmon calcitonin." Regulatory peptides 117.3 (2004): 159-166.

Lutz, T. A., et al. "Amylin receptors mediate the anorectic action of salmon calcitonin (sCT)." Peptides 21.2 (2000): 233-238.