[Lys3] - Bombesin

Description:

An immunoconjugate of [Lys3]-bombesin can specifically induce (CD64)-dependent monocyte and neutrophil-mediated lysis of small cell carcinoma.

Sequence:

{pGLU}-QKLGNQWAVGHLM-NH2

General

References

Comments (0)

Name	[Lys3] - Bombesin
Category	Bombesin and Bombesin Antagonists
One Letter Code	{pGLU}-QKLGNQWAVGHLM-NH2
Three Letter Code	{pGLU}{Gln}{Lys}{Leu}{Gly}{Asn}{Gln}{Trp}{Ala}{Val}{Gly}{His}{Leu}{Met}-NH2
Molecular Weight	1591.900
Application	Cancer Research

Chen, Xiaoyuan, et al. "microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3] bombesin in human prostate adenocarcinoma xenografts." Journal of Nuclear Medicine 45.8 (2004): 1390-1397.

Baidoo, Kwamena E., et al. "Design, synthesis, and initial evaluation of high-affinity technetium bombesin analogues." Bioconjugate chemistry 9.2 (1998): 218-225.

Jiménez‐Mancilla, Nallely, et al. "Multifunctional targeted therapy system based on 99mTc/177Lu‐labeled gold nanoparticles‐Tat (49–57)‐Lys3‐bombesin internalized in nuclei of prostate cancer cells." Journal of Labelled Compounds and Radiopharmaceuticals 56.13 (2013): 663-671.

Ferro-Flores, G., et al. "Click chemistry for [99mTc (CO) 3] labeling of Lys3-bombesin." Applied radiation and isotopes 68.12 (2010): 2274-2278.

Santos-Cuevas, Clara L., et al. "Design, preparation, in vitro and in vivo evaluation of 99mTc-N2S2-Tat (49–57)-bombesin: a target-specific hybrid radiopharmaceutical." International journal of pharmaceutics 375.1-2 (2009): 75-83.