Beta - Amyloid (17 - 40)

Description:

Cleavage of APP by alpha- and gamma-secretase yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.

Sequence:

LVFFAEDVGSNKGAIIGLMVGGVV

General

References

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Name	Beta - Amyloid (17 - 40)
Category	Beta-Amyloidand Related Peptides
One Letter Code	LVFFAEDVGSNKGAIIGLMVGGVV
Three Letter Code	{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	2392.900
Application	Alzheimer's Disease

Jang, Hyunbum, et al. "Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer’s disease and Down syndrome." Proceedings of the National Academy of Sciences 107.14 (2010): 6538-6543.

Dulin, Fabienne, et al. "p3 peptide, a truncated form of Aβ devoid of synaptotoxic effect, does not assemble into soluble oligomers." FEBS letters 582.13 (2008): 1865-1870.