(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21)

Description:

The pentapeptide LPFFD (iAβ5), a highly efficient β-sheet breaker, inhibited amyloid formation in vitro, prevented amyloid neurotoxicity in cell culture, reduced in vivo cerebral Aβ deposition and completely blocked amyloid fibril formation in rat brain.

Sequence:

LPFFD

General

References

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Name	(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21)
Category	Beta-Amyloidand Related Peptides
One Letter Code	LPFFD
Three Letter Code	{Leu}{Pro}{Phe}{Phe}{Asp}
Molecular Weight	637.730
Application	Alzheimer's Disease

Rocha, Sandra, et al. "Design and biological activity of β-sheet breaker peptide conjugates." Biochemical and biophysical research communications 380.2 (2009): 397-401.

Viet, Man Hoang, et al. "Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity." The Journal of Physical Chemistry B 115.22 (2011): 7433-7446.

Murvai, Ünige, et al. "Effect of the beta‐sheet‐breaker peptide LPFFD on oriented network of amyloid β25‐35 fibrils." Journal of Molecular Recognition 24.3 (2011): 453-460.

Soto, Claudio, et al. "β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy." Nature medicine 4.7 (1998): 822-826.