Beta - Amyloid (16 - 22)

Description:

This is self-assembling Aβ sequence containing two aromatic phenylalanine residues. Aromatic interactions are important in many cases of amyloid formation.This heptapeptide fragment has the capacity of forming typical amyloid fibrils in vitro.

Sequence:

KLVFFAE

General

References

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Name	Beta - Amyloid (16 - 22)
Category	Beta-Amyloidand Related Peptides
One Letter Code	KLVFFAE
Three Letter Code	{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}
Molecular Weight	853.000
Application	Alzheimer's Disease

Gazit, Ehud. "Mechanisms of amyloid fibril self‐assembly and inhibition: Model short peptides as a key research tool." The FEBS journal 272.23 (2005): 5971-5978.

Balbach, John J., et al. "Amyloid fibril formation by Aβ16-22, a seven-residue fragment of the Alzheimer's β-amyloid peptide, and structural characterization by solid state NMR." Biochemistry 39.45 (2000): 13748-13759.

Tao, Kai, et al. "Self-assembly of short Aβ (16− 22) peptides: Effect of terminal capping and the role of electrostatic interaction." Langmuir 27.6 (2011): 2723-2730.

Klimov, Dmitri K., and D. Thirumalai. "Dissecting the assembly of Aβ16–22 amyloid peptides into antiparallel β sheets." Structure 11.3 (2003): 295-307.