Amyloid β-Protein (16-20)

Description:

The KLVFF sequence is the minimum sequence binding the full-length amyloid β-protein.The pentapeptide acts as a β-sheet breaker.

Sequence:

KLVFF

General

References

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Name	Amyloid β-Protein (16-20)
Category	Beta-Amyloidand Related Peptides
One Letter Code	KLVFF
Three Letter Code	{Lys}{Leu}{Val}{Phe}{Phe}
Molecular Weight	652.840
Application	Alzheimer's Disease

Viet, Man Hoang, et al. "Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity." The Journal of Physical Chemistry B 115.22 (2011): 7433-7446.

Akikusa, S., et al. "Practical assay and molecular mechanism of aggregation inhibitors of β‐amyloid." The Journal of peptide research 61.1 (2003): 1-6.

Tjernberg, Lars O., et al. "Arrest of-amyloid fibril formation by a pentapeptide ligand." Journal of Biological Chemistry 271.15 (1996): 8545-8548.