Amyloid β-Protein (31-35)

Description:

Amyloid β-Protein (31-35) induced apoptosis in undifferentiated PC 12 cells.

Sequence:

IIGLM

General

References

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Name	Amyloid β-Protein (31-35)
Category	Beta-Amyloidand Related Peptides
One Letter Code	IIGLM
Three Letter Code	{Ile}{Ile}{Gly}{Leu}{Met}
Molecular Weight	545.740
Application	Alzheimer's Disease

Maloney, Bryan, and Debomoy K. Lahiri. "The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif." Gene 488.1-2 (2011): 1-12.

Bailey, Jason A., et al. "Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis." Gene 488.1-2 (2011): 13-22.

Misiti, Francesco, et al. "Fragment 31–35 of β-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation: A crucial role for the redox state of methionine-35 residue." Neurochemistry international 49.5 (2006): 525-532.

Clementi, M. Elisabetta, et al. "Aβ (31–35) and Aβ (25–35) fragments of amyloid beta‐protein induce cellular death through apoptotic signals: Role of the redox state of methionine‐35." FEBS letters 579.13 (2005): 2913-2918.