Beta - Amyloid (4 - 42)

Description:

Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. It may contribute to the development of multiple CNS diseases

Sequence:

FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

General

References

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Name	Beta - Amyloid (4 - 42)
Category	Beta-Amyloidand Related Peptides
One Letter Code	FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	4198.800
Application	Alzheimer's Disease

Antonios, Gregory, et al. "N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody." Acta neuropathologica communications 1.1 (2013): 56.

Bouter, Yvonne, et al. "N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits." Acta neuropathologica 126.2 (2013): 189-205.

Portelius, Erik, et al. "Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease." Acta neuropathologica 120.2 (2010): 185-193.

Tomidokoro, Yasushi, et al. "Familial Danish dementia co-existence of Danish and Alzheimer amyloid subunits (ADan and Aβ) in the absence of compact plaques." Journal of Biological Chemistry 280.44 (2005): 36883-36894.