Beta - Amyloid (11 - 40)

Description:

This is amino acids 11 to 40 fragment of beta-amyloid. Post-mortem AD brain specimens reveals significant levels of Aβ (11-40/42) within insoluble amyloid pools.

Sequence:

EVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

General

References

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Name	Beta - Amyloid (11 - 40)
Category	Beta-Amyloidand Related Peptides
One Letter Code	EVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Three Letter Code	{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	3151.700
Application	Alzheimer's Disease

Tjernberg, Lars O., et al. "A molecular model of Alzheimer amyloid β-peptide fibril formation." Journal of Biological Chemistry 274.18 (1999): 12619-12625.

Qahwash, Isam, et al. "Processing amyloid precursor protein at the β-site requires proper orientation to be accessed by BACE1." Journal of Biological Chemistry 279.37 (2004): 39010-39016.

Liu, Kangning, Robert W. Doms, and Virginia M-Y. Lee. "Glu11 site cleavage and N-terminally truncated Aβ production upon BACE overexpression." Biochemistry 41.9 (2002): 3128-3136.