Beta - Amyloid (3 - 42)

Description:

Aβ 3-42 is the precursor of the Pyr-peptide and may be formed in increased amounts as AD progresses.

Sequence:

EFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

General

References

Comments (0)

Name	Beta - Amyloid (3 - 42)
Category	Beta-Amyloidand Related Peptides
One Letter Code	EFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	4327.900
Application	Alzheimer's Disease

Becker, Andreas, et al. "Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration." BMC neuroscience 14.1 (2013): 108.

Wirths, Oliver, et al. "Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases." Journal of neural transmission 117.1 (2010): 85-96.

McColl, Gawain, et al. "The Caenorhabditis elegans Aβ1–42 model of Alzheimer disease predominantly expresses Aβ3–42." Journal of Biological Chemistry 284.34 (2009): 22697-22702.