APL1β28

Description:

A highly sensitive biomarker for the production of Aβ 1-42 derived from the βAPP-like protein APLP1.

Sequence:

DELAPAGTGVSREAVSGLLIMGAGGGSL

General

References

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Name	APL1β28
Category	Beta-Amyloidand Related Peptides
One Letter Code	DELAPAGTGVSREAVSGLLIMGAGGGSL
Three Letter Code	{Asp}{Glu}{Leu}{Ala}{Pro}{Ala}{Gly}{Thr}{Gly}{Val}{Ser}{Arg}{Glu}{Ala}{Val}{Ser}{Gly}{Leu}{Leu}{Ile}{Met}{Gly}{Ala}{Gly}{Gly}{Gly}{Ser}{Leu}
Molecular Weight	2585.920
Application	Alzheimer's Disease

Okochi, Masayasu, Shinji Tagami, and Masatoshi Takeda. "Analysis of APL1β28, a surrogate marker for Alzheimer Aβ42, indicates altered precision of γ-cleavage in the brains of Alzheimer disease patients." Neurodegenerative Diseases 7.1-3 (2010): 42-45.

Yanagida, Kanta, et al. "The 28‐amino acid form of an APLP1‐derived Aβ‐like peptide is a surrogate marker for Aβ42 production in the central nervous system." EMBO molecular medicine 1.4 (2009): 223-235.