[Arg6] - beta - Amyloid (1 - 40), English Mutation

Description:

This peptide is the mutant form of the Aβ 1-40. It accelerates fibrillation without increasing protofibril formation.

Sequence:

DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

General

References

Comments (0)

Name	[Arg6] - beta - Amyloid (1 - 40), English Mutation
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{Arg}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4348.900
Application	Alzheimer's Disease

Viet, M. H., et al. "ACS Chem. Neurosci." (2014).

Alies, Bruno, et al. "pH-Dependent Cu (II) coordination to amyloid-β peptide: impact of sequence alterations, including the H6R and D7N familial mutations." Inorganic chemistry 50.21 (2011): 11192-11201.

Ono, Kenjiro, Margaret M. Condron, and David B. Teplow. "Effects of the English (H6R) and Tottori (D7N) familial Alzheimer disease mutations on amyloid β-protein assembly and toxicity." Journal of Biological Chemistry 285.30 (2010): 23186-23197.

Hori, Yukiko, et al. "The Tottori (D7N) and English (H6R) familial Alzheimer disease mutations accelerate Aβ fibril formation without increasing protofibril formation." Journal of biological chemistry 282.7 (2007): 4916-4923.