(Arg¹³)-Amyloid β-Protein (1-40)

Description:

(Arg¹³)-Amyloid β-Protein (1-40) , a mutation in the metal-binding region of Aβ reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.

Sequence:

DAEFRHDSGYEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV

General

References

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Name	(Arg¹³)-Amyloid β-Protein (1-40)
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{Arg}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4348.910
Application	Alzheimer's Disease

Poduslo, Joseph F., et al. "HH domain of Alzheimer’s disease Aβ provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons." PLoS One 5.1 (2010).

Dai, Xueling, et al. "Copper enhances amyloid-β peptide neurotoxicity and non β-aggregation: a series of experiments conducted upon copper-bound and copper-free amyloid-β peptide." Journal of molecular neuroscience 41.1 (2010): 66-73.

Smith, David P., et al. "Copper-mediated amyloid-β toxicity is associated with an intermolecular histidine bridge." Journal of Biological Chemistry 281.22 (2006): 15145-15154.