[Pro19] - beta - Amyloid (1 - 42); F19P beta - Amyloid (1 - 42),

Description:

This peptide is the mutant form of the Aβ1-42. It inhibits amyloid fibril formation, which is implicated in neurodegenerative diseases such as Alzheimer’s.

Sequence:

DAEFRHDSGYEVHHQKLVPFAEDVGSNKGAIIGLMVGGVVIA

General

References

Comments (0)

Name	[Pro19] - beta - Amyloid (1 - 42); F19P beta - Amyloid (1 - 42),
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVPFAEDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Pro}{Phe}{Ala}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	4464.100
Application	Alzheimer's Disease

Bernstein, Summer L., et al. "Amyloid β-protein: monomer structure and early aggregation states of Aβ42 and its Pro19 alloform." Journal of the American Chemical Society 127.7 (2005): 2075-2084.

O'Nuallain, Brian, and Ronald Wetzel. "Conformational Abs recognizing a generic amyloid fibril epitope." Proceedings of the National Academy of Sciences 99.3 (2002): 1485-1490.