[Gly21] - beta - Amyloid (1 - 42), A21G Flemish Mutation

Description:

This peptide is the mutant form of the Aβ1-42.The Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity.

Sequence:

DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVVIA

General

References

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Name	[Gly21] - beta - Amyloid (1 - 42), A21G Flemish Mutation
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Gly}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	4500.100
Application	Alzheimer's Disease

Matos, Ana M., et al. "Synthesis and effects of flavonoid structure variation on amyloid-β aggregation." Pure and Applied Chemistry 89.9 (2017): 1305-1320.

Huet, Alexis, and Philippe Derreumaux. "Impact of the mutation A21G (Flemish variant) on Alzheimer’s β-amyloid dimers by molecular dynamics simulations." Biophysical journal 91.10 (2006): 3829-3840.