[Gly21] - beta - Amyloid (1 - 40), A21G, Flemish Mutation

Description:

This peptide is the mutant form of the Aβ1-40. Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity.

Sequence:

DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV

General

References

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Name	[Gly21] - beta - Amyloid (1 - 40), A21G, Flemish Mutation
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Gly}{Glu}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4315.900
Application	Alzheimer's Disease

Huet, Alexis, and Philippe Derreumaux. "Impact of the mutation A21G (Flemish variant) on Alzheimer’s β-amyloid dimers by molecular dynamics simulations." Biophysical journal 91.10 (2006): 3829-3840.

Jan, Asad, Dean M. Hartley, and Hilal A. Lashuel. "Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research." Nature protocols 5.6 (2010): 1186.

Betts, V., et al. "A facile method for expression and purification of the Alzheimer’s disease-associated amyloid β-peptide." Neurobiol. Dis 31 (2008): 442-450.

Tsubuki, Satoshi, Yoshie Takai, and Takaomi C. Saido. "Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Aβ to physiologically relevant proteolytic degradation." The Lancet 361.9373 (2003): 1957-1958.

Kumar-Singh, Samir, et al. "In vitro studies of Flemish, Dutch, and wild-type β-amyloid provide evidence for two-staged neurotoxicity." Neurobiology of disease 11.2 (2002): 330-340.