[Lys22] - beta - Amyloid (1 - 42), Italian Mutation

Description:

This is amino acids 1 to 42 fragment of the beta-amyloid peptide with lysine substituted for glutamic acid at position 22 found in Italian families. The Italian mutation of beta -amyloid 1 to 42 (E22K) aggregates more rapidly than wild-type beta-amyloid (1-42). It showed increased neurotoxicity

Sequence:

DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVVIA

General

References

Comments (0)

Name	[Lys22] - beta - Amyloid (1 - 42), Italian Mutation
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVVIA
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Lys}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}{Ile}{Ala}
Molecular Weight	4513.200
Application

Masuda, Yuichi, et al. "Verification of the turn at positions 22 and 23 of the β-amyloid fibrils with Italian mutation using solid-state NMR." Bioorganic & medicinal chemistry 13.24 (2005): 6803-6809.