[Gly22] - beta - Amyloid (1 - 40), Arctic Mutation

Description:

The highly neurotoxic arctic mutant of Aβ 40 has been used to study the mechanisms underlying the formation of soluble and insoluble β-amyloid aggregates.

Sequence:

DAEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVV

General

References

Comments (0)

Name	[Gly22] - beta - Amyloid (1 - 40), Arctic Mutation
Category	Beta-Amyloidand Related Peptides
One Letter Code	DAEFRHDSGYEVHHQKLVFFAGDVGSNKGAIIGLMVGGVV
Three Letter Code	{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}{Val}{His}{His}{Gln}{Lys}{Leu}{Val}{Phe}{Phe}{Ala}{Gly}{Asp}{Val}{Gly}{Ser}{Asn}{Lys}{Gly}{Ala}{Ile}{Ile}{Gly}{Leu}{Met}{Val}{Gly}{Gly}{Val}{Val}
Molecular Weight	4257.800
Application	Alzheimer's Disease

Bolognesi, Benedetta, et al. "ANS binding reveals common features of cytotoxic amyloid species." ACS chemical biology 5.8 (2010): 735-740.

Jan, Asad, Dean M. Hartley, and Hilal A. Lashuel. "Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research." Nature protocols 5.6 (2010): 1186.

Solito, Raffaella, et al. "Dutch and arctic mutant peptides of β amyloid1–40 differentially affect the FGF-2 pathway in brain endothelium." Experimental cell research 315.3 (2009): 385-395.

Lam, A. R., et al. "Effects of the Arctic (E22→ G) mutation on amyloid β-protein folding: discrete molecular dynamics study." Journal of the American Chemical Society 130.51 (2008): 17413-17422.

Yamamoto, Naoki, et al. "A Ganglioside-induced Toxic Soluble Aβ Assembly ITS ENHANCED FORMATION FROM AβBEARING THE ARCTIC MUTATION." Journal of Biological Chemistry 282.4 (2007): 2646-2655.